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There is no information on overdosage situations involving PHOTOFRIN. Higher than recommended drug doses of two 2 mg/kg doses given tow days apart (10 patients) and three 2 mg/kg doses given within two weeks (1 patient) were tolerated without notable adverse reactions. Effects of overdosage on the duration of photosensitivity are unknown. Laser treatments should not be given if an overdose of PHOTOFRIN is administered. In the event of an overdose, patients should protect their eyes and skin from direct sunlight or bright indoor lights for 30 days. At this time, patients should test for residual photosensitivity. PHOTOFRIN is not dialyzable.
Light doses of two to three times the recommended dose have been administered to a few patients with superficial endobronchial tumors. One patient experienced life-threatening dyspnea and the others had no notable complications. Increased symptoms and damage to normal tissue might be expected following an overdose of light.
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Division of Thoracic Surgery
Brigham and Women's Hospital
75 Francis Street
Boston, MA 02115